Major Metabolites of Zolpidem : Expeditious Synthesis and Mass Spectra KLUPSCH Frederique HOUSSIN Raymond HUMBERT Luc IMBENOTTE Michel HENICHART Jean-Pierre LHERMITTE Michel 公益社団法人日本薬学会 Chemical & pharmaceutical bulletin 00092363 54 9 1318 1321 2006-09-01 An expeditious route to the two major metabolites of Zolpidem-and readily applicable to the synthesis of the drug-was established via a cyclization reaction between a 2-aminopyridine and a suitable α-bromoace-tophenone. The structures of the target compounds were confirmed from a 2D ^1H-^<15>N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes. 2006-09-01 110004836457 AA00602100 8027098 ENG CJP NDL NII-ELS J-STAGE 3 18 Major Metabolites of Zolpidem : Expeditious Synthesis and Mass Spectra KLUPSCH Frederique HOUSSIN Raymond HUMBERT Luc IMBENOTTE Michel HENICHART Jean-Pierre LHERMITTE Michel The Pharmaceutical Society of Japan Chemical & pharmaceutical bulletin An expeditious route to the two major metabolites of Zolpidem-and readily applicable to the synthesis of the drug-was established via a cyclization reaction between a 2-aminopyridine and a suitable α-bromoace-tophenone. The structures of the target compounds were confirmed from a 2D ^1H-^<15>N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes. KLUPSCH Frederique Institut de Chimie Pharmaceutique Albert Lespagnol HOUSSIN Raymond Institut de Chimie Pharmaceutique Albert Lespagnol HUMBERT Luc Laboratoire de Toxicologie et Genopathies, Hopital A. Calmette, CHRU IMBENOTTE Michel Laboratoire de Toxicologie, Faculte des Sciences Pharmaceutiques et Biologiques HENICHART Jean-Pierre Institut de Chimie Pharmaceutique Albert Lespagnol LHERMITTE Michel Laboratoire de Toxicologie et Genopathies, Hopital A. Calmette, CHRU Laboratoire de Toxicologie, Faculte des Sciences Pharmaceutiques et Biologiques