Major Metabolites of Zolpidem : Expeditious Synthesis and Mass Spectra

    • HUMBERT Luc
    • Laboratoire de Toxicologie et Genopathies, Hopital A. Calmette, CHRU
    • IMBENOTTE Michel
    • Laboratoire de Toxicologie, Faculte des Sciences Pharmaceutiques et Biologiques
    • LHERMITTE Michel
    • Laboratoire de Toxicologie et Genopathies, Hopital A. Calmette, CHRU:Laboratoire de Toxicologie, Faculte des Sciences Pharmaceutiques et Biologiques

Abstract

An expeditious route to the two major metabolites of Zolpidem-and readily applicable to the synthesis of the drug-was established via a cyclization reaction between a 2-aminopyridine and a suitable α-bromoace-tophenone. The structures of the target compounds were confirmed from a 2D ^1H-^<15>N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes.

Journal

Chemical & pharmaceutical bulletin   [Journal Detail]

Chemical & pharmaceutical bulletin  54(9)  pp.1318-1321 20060901  [Index]

The Pharmaceutical Society of Japan

References:  18

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Codes

  • NII Article ID (NAID)：
    110004836457
  • NII NACSIS-CAT ID (NCID)：
    AA00602100
  • Text Lang：
    ENG
  • Article Type：
    NOT
  • ISSN：
    00092363
  • NDL Article ID：
    0619191100
  • NDL Source Classification：
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No.：
    Z53-D167
  • Databases：
    CJP書誌  NDL  NII-ELS  J-STAGE 

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