Comparative Study of Chemical Constituents of Rhubarb from Different Origins

    • KOMATSU Katsuko
    • Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama:21st Century COE Program, University of Toyama
    • NAGAYAMA Yorinobu
    • Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama
    • TANAKA Ken
    • Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama
    • CAI Shao-Qing
    • Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University
    • OMOTE Takayuki
    • Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama

Abstract

A comparative study of the pharmacologically active constituents of 24 rhubarb samples, which were identified genetically as Rheum tanguticum, 3 intraspecies groups of R. palmatum and R. officinale, was conducted using reversed-phase high performance liquid chromatography (HPLC) methods. Thirty compounds belonging to anthraquinones, anthraquinone glucosides, dianthrones, phenylbutanones, stilbenes, flavan-3-ols, procyanidins, galloylglucoses, acylglucoses, gallic acid, and polymeric procyanidins were analyzed quantitatively. The drug samples derived from the same botanical source showed similar chromatographic profiles, and the comparable specific shape that appeared in the 10-directed radar graphs constructed on the basis of the results of quantitative analysis indicated the relationship between chemical constituent patterns and genetic varieties of rhubarb samples.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 54(11), 1491-1499, 2006-11-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  29

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Codes

  • NII Article ID (NAID) :
    110004836468
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    00092363
  • NDL Article ID :
    8516468
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.54.1491
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE