Structures of New Flavonoids, Erycibenins D, E, and F, and NO Production Inhibitors from Erycibe expansa Originating in Thailand

Abstract

A new flavanol, erycibenin D, and two new flavans, erycibenins E and F, were isolated from the stems of Erycibe expansa originating in Thailand. The structures of new flavonoids were elucidated on the basis of chemical and physicochemical evidence. In addition, the inhibitory activities of the isolated constituents from E. expansaon lipopolysaccharide-activated nitric oxide production in mouse peritoneal macrophages were examined. Among the principal constituents, two isoflavones, clycosin (IC_<50>=13μM) and erythrinin B (18μM), and two rotenoids, deguelin (26μM) and rotenone (27μM), were found to show potent inhibitory activity.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 54(11), 1530-1534, 2006-11-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  54

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Cited by:  6

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Codes

  • NII Article ID (NAID) :
    110004836472
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    8516517
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.54.1530
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE