Function of an N-Heterocyclic Carbene Ligand Based on Concept of Chiral Mimetic

    • ARAO Takafumi
    • Graduate School of Pharmaceutical Sciences, Nagoya City University
    • SATO Kei
    • Graduate School of Pharmaceutical Sciences, Nagoya City University
    • KONDO Kazuhiro
    • Graduate School of Pharmaceutical Sciences, Nagoya City University

Abstract

Function of a new N-heterocyclic carbene ligand based on the concept of a chiral mimetic is described. With (4R, 5R)-4,5-diphenyl-1,3-dialkyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborates as N-heterocyclic carbene precursors, Rh-catalyzed enantioselective arylation (up to 27% ee) of aromatic aldehydes with arylboronic acids and Pd-catalyzed enantioselective intramolecular α-arylation (up to 66% ee) of N-(2-bromoaryl)-N-alkyl-2-aryl-propanamides are investigated.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 54(11), 1576-1581, 2006-11-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  28

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Cited by:  1

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Codes

  • NII Article ID (NAID) :
    110004836479
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    8516631
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.54.1576
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE