Sesquiterpene Coumarins from the Roots of Ferula sinkiangensis and Ferula teterrima

  • Yang Jun-Rong
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education
  • An Zheng
    Department of Neurology, China–Japan Friendship Hospital
  • Li Zhi-Hong
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education
  • Jing Song
    Xin Jiang Yi Li Prefecture Institute for Drug Control
  • Qina Hai-Lin
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education

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抄録

Three new natural sesquiterpene coumarins, isofeterin (1), lehmannolol (3), sinkianone (4), and one known compound, lehmannolone (2), were isolated from the roots of Ferula teterrima and Ferula sinkiangensis. Their chemical structures were established on the basis of spectroscopic analysis, including X-ray crystallography and CD spectrum measurements for determining the absolute configuration of compound 2.

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