鵜飼に用いられた飼育下ウミウ(Phalacrocorax capillatus)における痛風(病理学) 中村 光孝 松井 直哉 高島 久幸 林 登 酒井 洋樹 柳井 徳磨 柵木 利昭 日本野生動物医学会 Japanese journal of zoo and wildlife medicine 13426133 11 2 73 77 2006-09 1952年から2004年において剖検された,115例の鵜飼に従事していた飼育下ウミウ(Phalacrocorax capillatus)のうち3例に痛風を認めた.剖検では,全例ともに内臓漿膜,特に心外膜および肝臓被膜は灰白色チョーク様尿酸塩の沈着により肥厚し,腎実質内にも尿酸塩沈着が認められた.病理組織学的には,肥厚した漿膜と尿管内に無構造好酸性尿酸塩が沈着,尿管上皮の角化重層扁平上皮化生が全例に認められた.また,尿管は偽好酸球浸潤を伴う尿酸塩および角化物の集積によって拡張していた.重度な2例では腎臓内に痛風結節の形成が見られた.肝臓,肺,腎臓および脾臓の血管内に尿酸塩の析出による尿酸塩栓子および血栓が認められた.以上より,ウミウの痛風において,尿酸塩栓子として見られる高尿酸塩血症の原因は尿管の角化扁平上皮化生による尿管の閉塞であり,加えて,腎尿酸塩沈着が高尿酸塩血症を促進し,全身的な高度の尿酸塩沈着をもたらしたと考えられた. 2006-09 110004836494 AA11366156 JPN CJP NII-ELS 1 28 Gout in Captive Japanese Cormorants (Phalacrocorax capillatus) Used for UKAI-A Traditional Japanese Fishing Method NAKAMURA Mitsutaka MATSUI Naoya TAKASHIMA Hisayuki HAYASHI Noboru SAKAI Hiroki YANAI Tokuma MASEGI Toshiaki Japanese Society of Zoo and Wildlife Medicine Japanese Journal of Zoo and Wildlife Medicine Among 115 necropsy cases (1952-2004) of captive Japanese cormorants that were used for UKAI-a traditional Japanese fishing method-three Japanese cormorants (Phalacrocorax capillatus) were diagnosed with gout on the basis of gross and histological findings. At necropsy, visceral serosa, especially pericardium and hepatic capsule, thickened by chalk-appearing urate were observed. Urate was also observed in the parenchyma of kidneys. Histopathologically, amorphous eosinophilic urate was heavily deposited in the thickened serosa and ureters. Severe squamous metaplasia and keratinization of the ureteral epithelium were observed, and the ureters had dilated due to the accumulation of urate and keratins along with the infiltration of the heterophils. Tophi were observed in the kidney of two severe cases. Uratic emboli and thrombi were formed in the blood vessels of the liver, lungs, kidneys, and spleen. The cause of hyperuricemia, which is indicated by uratic emboli in the vessels, is the obstruction of the ureter by squamous metaplasia and keratinization. In addition, renal uratic accumulation may promote hyperuricemia and result in heavy deposition of urates throughout the body. 中村 光孝 NAKAMURA Mitsutaka 岐阜県食肉衛生検査所 Gifu Prefecture Meat inspection Office 松井 直哉 MATSUI Naoya 岐阜県食肉衛生検査所 Gifu Prefecture Meat inspection Office 高島 久幸 TAKASHIMA Hisayuki 岐阜県中濃家畜保健衛生所 Gifu Prefecture Chunou Livestock Hygiene Service Center 林 登 HAYASHI Noboru 岐阜県畜産研究所 Gifu Prefecture Livestock Research Institute 酒井 洋樹 SAKAI Hiroki 岐阜大学応用生物科学部獣医学講座獣医病理学研究室 Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University 柳井 徳磨 YANAI Tokuma 岐阜大学応用生物科学部獣医学講座獣医病理学研究室 Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University 柵木 利昭 MASEGI Toshiaki 岐阜大学応用生物科学部獣医学講座獣医病理学研究室 Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University