Genotoxicity in Cell Lines Induced by Chronic Exposure to Water-Soluble Fullerenes Using Micronucleus Test
-
- NIWA Yasuharu
- Department of Epidemiology, Research Institute, National Cardiovascular Center
-
- IWAI Naoharu
- Department of Epidemiology, Research Institute, National Cardiovascular Center
この論文をさがす
抄録
Objectives: Nanomaterials have numerous potential benefits for society, but the effects of nanomaterials on human health are poorly understood. In this study, we aim to determine the genotoxic effects of chronic exposure to nanomaterials in various cell lines.<br> Methods: Chinese hamster ovary (CHO) cells, human epidermoid-like carcinoma (Hela) cells and human embryonic kidney 293 (HEK293) cells were treated with the water-soluble fullerene C60(OH)24 for 33–80 days. Cell proliferation, cytotoxic analysis and micronucleus tests were performed.<br> Results: When treated with C60(OH)24 (0, 10, 100, or 1000 pg/ml) for 33 days, both the HEK293 and Hela cells showed increased cell proliferation, but cellular lactate dehydrogenase (LDH) activity was not affected. After long-term exposure (80 days) to C60(OH)24 (0, 10, 100, or 1000 pg/ml), the CHO, Hela and HEK293 cells showed increased genotoxicity on the micronucleus test.<br> Conclusion: This study suggests that nanomaterials, such as C60(OH)24, have genotoxic effects.<br>
収録刊行物
-
- Environmental Health and Preventive Medicine
-
Environmental Health and Preventive Medicine 11 (6), 292-297, 2006
一般社団法人日本衛生学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679435046912
-
- NII論文ID
- 110004850844
-
- NII書誌ID
- AA1108348X
-
- COI
- 1:CAS:528:DC%2BD2sXhsV2hsL0%3D
-
- ISSN
- 13474715
- 1342078X
-
- PubMed
- 21432358
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可