Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome

DOI Web Site PubMed 被引用文献38件 参考文献61件
  • Fujita Koichi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Nishizawa Hitoshi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Funahashi Tohru
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Shimomura Iichiro
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Shimabukuro Michio
    Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus

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Background The metabolic syndrome (MetS) is a major target for prevention of atherosclerotic cardiovascular diseases and visceral fat accumulation is an underlying component of MetS. The aim of this study was to investigate the association of systemic oxidative stress with visceral fat accumulation and MetS. Methods and Results The study group consisted of Japanese men (n=44; 51.2±11.4 years) and women (n=61; 55.4 ±13.4 years). Urinary 8-epi-prostaglandin F2α (8-epi-PGF2 α) concentration, a biomarker of systemic oxidative stress, was significantly high in the subjects with MetS. As the urinary concentration of 8-epi-PGF2α increased, the number of criteria for MetS were significantly met (abdominal obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and high fasting glucose). Among parameters associated with MetS, the correlation coefficient of visceral fat area (VFA) with urinary 8-epi-PGF2α concentration was the highest (r=0.636, p<0.0001). In non-obese subjects, the correlation coefficient of VFA with urinary 8-epi-PGF2α concentration was higher (r=0.728, p<0.0001), although there was no significant correlation between subcutaneous fat area and urinary 8-epi-PGF2 α. Stepwise multiple regression analysis identified VFA as the strongest and independent determinant of urinary 8-epi-PGF2 α (p<0.0001) followed by adiponectin (p=0.0212) and, high sensitive C-reactive protein (p=0.0365). Conclusions Systemic oxidative stress, as measured by urinary 8-epi-PGF2α , is strongly associated with visceral fat accumulation and MetS. (Circ J 2006; 70: 1437 - 1442)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 70 (11), 1437-1442, 2006

    一般社団法人 日本循環器学会

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