口腔アレルギー症候群と各種花粉感作,特にヨモギ花粉感作との関連性  [in Japanese] RELATIONSHIPS BETWEEN ORAL ALLERGY SYNDROME AND SENSITIZATION TO POLLEN ANTIGEN, ESPECIALLY TO MUGWORT  [in Japanese]

【背景,目的】本邦におけるヨモギ花粉症とOASの関連を調べる目的で,ヨモギ花粉症の多い室蘭市において調査を行った.【方法】1998〜2002年に市立室蘭総合病院耳鼻科を受診したアレルギー性鼻炎患者のうち,シラカバ,ヨモギおよびカモガヤのいずれかに対する血清特異的IgE抗体陽性のものを調査対象とし,郵送によるOASに関するアンケート調査を行った.【結果】OAS出現頻度は,シラカバ花粉抗原特異的IgE抗体陽性例あるいはヨモギ花粉抗原特異的IgE抗体陽性例がそれぞれの抗体陰性例よりも有意に高かった(シラカバ; 54.5vs23.5%,p<0.0001,ヨモギ; 41.Ovs21.5%, p<0.01).OAS原因食物は,シラカバ特異抗体のみ陽性の患者ではバラ科の果物が多く,ヨモギ特異抗体のみ陽性の患者では,キウイ,メロン,ミカン,セロリ,タマネギなどバラ科以外の食物がほとんどであった.ヨモギLumiwardスコアの高い患者の中に重症なOAS例が多く含まれる傾向を認めた.【結語】ヨモギ花粉感作とOASの密接な関連性が示唆された.

Background: In order to know the relationships between mugwort pollinosis and oral allergy syndrome (OAS), an etiological study was performed at Muroran City, where mugwort is the most frequent cause of pollinosis. Methods: Allergic rhinitis patients positive to serum IgE to birch, mugwort or grass pollen visited to the outpatient-clinic of Otorhinolaryngology of Muroran City General Hospital from 1998 to 2002, were studied by a questionnaire concerning a past-history of OAS. Results: The prevalence of OAS was significantly higher in patients positive to serum IgE antibody specific to birch pollen or mugwort pollen than those negative to each pollen-specific antibody (birch; 54.5 vs 23.5%, p<0.0001, mugwort; 41.0 vs 21.5%,p<0.01). The main causative foods were fruits of rose family in patients with only birch pollen-specific IgE antibody, and were those other than rose family, such as kiwi, melon, orange, celery and onion in those with only mugwort pollen-specific IgE antibody. The patients group with high Lumiward score to mugwort pollen tended to include severe OAS cases. Conclusion: A close relationship was suggested between mugwort pollen sensitization and OAS.