Asymmetric Construction of Quaternary Carbon Stereocenter by Pd-Catalyzed Intramolecular α-Arylation

    • ARAO Takafumi
    • Graduate School of Pharmaceutical Sciences, Nagoya City University
    • KONDO Kazuhiro
    • Graduate School of Pharmaceutical Sciences, Nagoya City University

Abstract

The catalyst comprised of Pd(OAc)_2 and H_8-BINAP provides good reaction conversions for a catalytic enantioselective intramolecular α-arylation of N-(2-bromophenyl)-N-methyl-2-arylpropanamide to form the quaternary carbon with up to 68% enantioselectivity.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 54(12), 1743-1744, 2006-12-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  19

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Codes

  • NII Article ID (NAID) :
    110004863653
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    00092363
  • DOI :
    10.1248/cpb.54.1743
  • Databases :
    CJP  NII-ELS  J-STAGE