Apolipoprotein E Polymorphism Influences Lipid Phenotypes in Chinese Families With Familial Combined Hyperlipidemia

• Pei Wei-Dong

  Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)

• Zhang Yan-Hong

  Department of Biology, Graduate School of the Chinese Academy of Sciences

• Sun Yu-Hua

  Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)

• Gu Yu-Chun

  Department of Physiology, School of Medicine, Birmingham University

• Wang Yan-Fen

  Department of Biology, Graduate School of the Chinese Academy of Sciences

• Zhang Chao-Yang

  Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)

• Zhang Jian

  Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)

• Liu Li-Sheng

  Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)

• Hui Ru-Tai

  Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)

• Liu Yu-Qing

  Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)

• Yang Yue-Jin

  Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)

抄録

Background Apolipoprotein E (apoE) polymorphism is associated with changes in the lipoprotein profile of individuals with familial combined hyperlipidemia (FCHL), but its effects on the lipoprotein profiles of members of Chinese families with FCHL remain uncertain. Methods and Results 43 FCHL families (n=449) and 9 normolipidemic families (n=73) were recruited to assess the influence of apoE polymorphism on plasma lipids. The relative frequency of the ε4 allele in affected and unaffected FCHL relatives, spouses and normolipidemic members was 13.8%, 5.3%, 9.1% and 6.8%, respectively, with a significantly higher frequency in affected FCHL relatives, compared with unaffected FCHL relatives or normolipidemic members (p=0.0002 or p=0.029). In FCHL relatives, the apoE4 subset (E4/4 and E4/3) exhibited significantly higher levels of apoB, total cholesterol and low-density lipoprotein-cholesterol (LDL-C) than did the apoE3 (E3/3) subset, especially in women (all p<0.05), and there was significant elevation of LDL-C concentrations in men only (p<0.05). In men, the apoE2 (E3/2) subset indicated a decreased level of apoB and increased apoA1 compared with those in the apoE3 subset (p<0.05). Conclusions ApoE polymorphism appears to be associated with variance of the lipoprotein phenotype in Chinese families with FCHL. (Circ J 2006; 70: 1606 - 1610)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 70 (12), 1606-1610, 2006

  一般社団法人 日本循環器学会

キーワード

• ApoE
• Familial combined hyperlipidemia
• Genotypes

詳細情報

• CRID: 1390001205105704576
• NII論文ID: 110005518981
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.70.1606
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/70/12/70_12_1606/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007143040
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
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