Inhibitory Effects of Magnolol on Distal Colon of Guinea Pig in Vitro

• Bian Zhao Xiang

  School of Chinese Medicine, Hong Kong Baptist University

• Zhang Gen Shui

  School of Chinese Medicine, Hong Kong Baptist University Guangzhou College of Medicine

• Wong Ka Leung

  School of Chinese Medicine, Hong Kong Baptist University

• Hu Xu Guang

  School of Chinese Medicine, Hong Kong Baptist University Guangzhou College of Pharmacy

• Liu Liang

  School of Chinese Medicine, Hong Kong Baptist University

• Yang Zhijun

  School of Chinese Medicine, Hong Kong Baptist University

• Li Min

  School of Chinese Medicine, Hong Kong Baptist University

抄録

The influence of plant product magnolol (0—100 μM) on the contractile activity of isolated colonic muscle strips in guinea pig and related mechanism were investigated. Magnolol did not affect the base tone of colon muscle strips, but it dose-dependently inhibited 40 mM KCl-, 1 μM carbachol (CCh)- and 10 μM serotonin (5-HT)-induced contractions at concentrations higher than 10 μM. And also, magnolol inhibited the 5-HT- or CCh-induced muscle contraction in calcium-free buffer. Furthermore, magnolol inhibited the KCl-induced contraction under the condition of procaine. In addition, inhibition rate of nifedipine plus magnolol on muscle strips was lower than that of nifedipine alone. Moreover, magnolol dose-dependently decreased the velocity of pellet propulsion in the concentration range of 0.1—10 μM, and totally inhibited pellet propulsion at the concentration higher than 30 μM. Thus, it can be concluded that magnolol may 1) block receptor-operated cation channels and the voltage dependent Ca²⁺ channel, and 2) inhibit calcium release from the sarcolemmal membrane (SR) through blocking InsP₃-sensitive and ryanodine-sensitive pathways. This explains, at least partially, that Cortex magnoliae officinalis exerts therapeutic effects on gastrointestinal disease through relaxation of GI tract smooth muscles.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 29 (4), 790-795, 2006

  公益社団法人 日本薬学会

キーワード

• magnolol
• smooth muscle
• Ca²⁺ channel

詳細情報

• CRID: 1390001204627966848
• NII論文ID: 110005602187
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.29.790
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7861922
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7861922
• Web Site: http://www.jstage.jst.go.jp/article/bpb/29/4/29_4_790/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007050224
• 本文言語コード: en
• データソース種別:
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