Relaxant Effect of Xanthomicrol and 3α-Angeloyloxy-2α-hydroxy-13,14Z-dehydrocativic Acid from Brickellia paniculata on Rat Uterus

• Ponce-Monter Hector

  ICSA, Universidad Autónoma del Estado de Hidalgo

• Perez Salud

  Departamento de Sistemas Biológicos, Unidad Xochimilco, Universidad Autónoma Metropolitana

• Zavala Miguel Angel

  Departamento de Sistemas Biológicos, Unidad Xochimilco, Universidad Autónoma Metropolitana

• Perez Cuauhtemoc

  Departamento de Sistemas Biológicos, Unidad Xochimilco, Universidad Autónoma Metropolitana

• Meckes Mariana

  Unidad de Investigación Médica en Farmacología de Productos Naturales, Centro Médico Nacional Siglo XXI

• Macias Arturo

  ICSA, Universidad Autónoma del Estado de Hidalgo

• Campos María

  Unidad de Investigación Médica en Farmacología, Centro Médico Nacional Siglo XXI

書誌事項

タイトル別名

• Relaxant Effect of Xanthomicrol and 3.ALPHA.-Angeloyloxy-2.ALPHA.-hydroxy-13,14Z-dehydrocativic Acid from Brickellia paniculata on Rat Uterus
• Relaxant Effect of Xanthomicrol and 3 アルファ Angeloyloxy 2 アルファ hydroxy 13 14Z dehydrocativic Acid from Brickellia paniculata on Rat Uterus

抄録

Brickellia paniculata has been used as spasmolytic in Mexican traditional medicine. Xanthomicrol and 3α-angeloyloxy-2α-hydroxy-13,14Z-dehydrocativic acid (AAHDD) are two of the main leaf components with antispasmodic activity. However, their mechanism of action remains unknown. An in vitro comparative study between xanthomicrol and AAHDD on rat uterus precontracted by either KCl (60 mM) or oxytocin (10 mIU/ml) was carried out to investigate the mechanism of action of these compounds on smooth muscle. Relaxant effect was measured as median inhibitory concentration (IC₅₀) and maximal effect as maximal relaxant response (R_max). Xanthomicrol was significantly more potent than AAHDD in inhibiting contractions induced by KCl 60 mM, whereas AAHDD was more potent than xanthomicrol in inhibiting contractions induced by oxytocin 10 mIU/ml. These results suggest that xanthomicrol induces a greater blocking effect on voltage-operated calcium channels than on receptor-operated gates.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 29 (7), 1501-1503, 2006

  公益社団法人 日本薬学会

キーワード

• <i>Brickellia paniculata</i>
• antispasmodic effect
• rat uterus

詳細情報

• CRID: 1390001204625977344
• NII論文ID: 110005602332
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.29.1501
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7960812
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7960812
• Web Site: http://www.jstage.jst.go.jp/article/bpb/29/7/29_7_1501/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007159789
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可