Inhibitory Activities of Plastoquinones and Chromene Derivative from a Brown Alga Sagassum micracanthum on Bone Resorption
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- Komai Eiko
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Miyahara Tatsuro
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Mori Jun
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Department of Pharmaceutical Research, Lead Chemical Co., Ltd.
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- Obi Nobuko
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Ochiai Hiroshi
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Saito Haruo
- Department of Pharmaceutical Research, Lead Chemical Co., Ltd.
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- Hayashi Toshimitsu
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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We evaluated inhibitory effects of plastoquinones (1, 2) and chromene derivative (3) from the methanol extract of Sargassum micracanthum on the differentiation of osteoclast progenitors into osteoclast-like cells (OCLs), bone-resorbing activity and the survival of OCLs. When OCL formation was investigated using osteoclast progenitor cells obtained from macrophage-colony stimulating factor (M-CSF)-treated mouse bone marrow, 1—3 inhibited dose-dependently OCL formation at the concentrations of 3—10 μM, the order of inhibitory potency being 1>3>2. In addition, they suppressed dose-dependently the pit formation induced by OCL on dentine slices, the order of inhibitory potency being 1>3>2. The survival of OCLs was inhibited by about 35, 45 and 60% in the presence of 6 μM of 2, 3 and 1, respectively. These results suggest that the inhibitory effects of the three compounds on the differentiation, pit formation and the survival of OCLs might contribute to the suppression of bone resorption.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 29 (9), 1980-1982, 2006
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679601761024
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- NII論文ID
- 110005602375
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8027033
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 使用不可