Assessment of Clonidine Orally Disintegrating Tablet for Pre-anesthetic Medication in Pediatric Surgery

• Homma Masato

  Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba Department of Pharmacy, Tsukuba University Hospital

• Sumiya Kenji

  Department of Pharmacy, Tsukuba University Hospital

• Kambayashi Yasuyuki

  Department of Pharmacy, Tsukuba University Hospital

• Inomata Shin-ichi

  Department of Anesthesiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Kohda Yukinao

  Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba Department of Pharmacy, Tsukuba University Hospital

抄録

The purpose of this study is to assess orally-disintegrating (OD) tablet of clonidine hydrochloride (CL) for a pre-operative sedation in pediatric surgery. Sedation score and plasma CL concentration of OD formulation was compared with original preparation, CL lollipop, in pediatric patients. Fourteen patients (age: 3.9±2.3 years, weight: 16.9±5.0 kg) for OD group and 9 patients (age: 4.4±3.1 years, weight: 17.2±7.0 kg) for lollipop group received 4 μg/kg of CL preparation. Pre-operative sedation was evaluated by 5-point scoring systems at entering the operating room. Plasma CL concentrations were determined 120 min after administration of CL preparation. The changes in systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were also assessed before and after administration of CL preparation. Every patients in OD group had satisfactory sedation (sedation score: 2 and 3), whereas, 3 (33%) in lollipop group had unsatisfactory sedation (sedation score: 0 and 1). Plasma CL concentration in OD group was significantly higher than those in lollipop group (0.75±0.15 vs. 0.42±0.21 ng/ml, p<0.01). There was no significant difference in hemodynamic parameters (SBP, DBP and HR) between before and after administration of CL preparation in both OD and lollipop group. We conclude that OD is superior preparation of CL for pre-operative sedation in pediatric surgery.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 29 (2), 321-323, 2006

  公益社団法人 日本薬学会

キーワード

• plasma clonidine concentration
• orally-disintegrating tablet
• pediatric sugery
• pre-anesthetic sedation

詳細情報

• CRID: 1390282679601071744
• NII論文ID: 110005663966
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.29.321
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7791926
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7791926
• Web Site: http://www.jstage.jst.go.jp/article/bpb/29/2/29_2_321/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006310176
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可