5α-Reductase Inhibitory Effect of Triterpenoids Isolated from Ganoderma lucidum(Miscellaneous)

    • LIU Jie
    • Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University
    • SHIMIZU Kuniyoshi
    • Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University
    • KONDO Ryuichiro
    • Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University

Abstract

5α-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.: FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5α-lanosta-7,9(11),24-triene-15α,26-dihydroxy-3-one with an IC_<50> of 10.6μM and 41.9μM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.

Journal

Biological & pharmaceutical bulletin   [List of Volumes]

Biological & pharmaceutical bulletin 29(2), 392-395, 2006-02-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  21

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Cited by:  4

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Codes

  • NII Article ID (NAID) :
    110005663981
  • NII NACSIS-CAT ID (NCID) :
    AA10885497
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    09186158
  • NDL Article ID :
    7792145
  • NDL Source Classification :
    ZS51(科学技術--薬学)
  • NDL Call No. :
    Z53-V41
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE 

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