Comparative Study of Two Different Structure of Collagen Scaffold for Bone Formation

DOI 参考文献3件
  • Rodriguez Andrea Paola
    Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Nagatsuka Hitoshi
    Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Huang Bingzhen
    Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Dental Titanium Giken
  • Rui Kan
    Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Dental Titanium Giken
  • Okauchi Mika
    Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Kagawa Yoshie
    Japan Institute for Advanced Dentistry
  • Liliana Missana
    Tucuman University
  • Oida Shinichiro
    Tsurumi University, Dental School
  • Nagai Noriyuki
    Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

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It has not been determined the best scaffold-structure for bone engineering. Because of this, we compared Honeycomb porous structure (HPS) and Interconnected porous structure (IPS) with or without KUSA/A1 cells implanted in mice. The transplants were subjected to radiological and histological examinations after 1,2,4 and 8 weeks of implantation.<br>KUSA/A1 cells alone showed small islands of new bone. Both scaffolds alone did not reveal any bone induction. KUSA/A1-HPS presented the scaffold partially filled with new bone. In contrast, KUSA/A1-IPS showed the whole scaffold filled with new bone. Our results indicated that cotton structure plays an important role in carrying the cells giving the precise size, shape and comfortable environment.

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