Substrate Selectivity of Monoamine Oxidase A, Monoamine Oxidase B, Diamine Oxidase, and Semicarbazide-Sensitive Amine Oxidase in COS-1 Expression Systems

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  • Ochiai Yoshinori
    Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University
  • Itoh Kunio
    Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University
  • Sakurai Eiichi
  • Adachi Mayuko
    Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University
  • Tanaka Yorihisa
    Department of Drug Metabolism and Pharmacokinetics, Tohoku Pharmaceutical University

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The substrate selectivity of monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), diamine oxidase (DAO), and semicarbazide-sensitive amine oxidase (SSAO) was investigated in the absence of chemical inhibitors using the COS-1 cells expressed with respective amine oxidase. Serotonin (5-hydroxytryptamine), 1-methylhistamine, and histamine were preferentially oxidized by MAO-A, SSAO, and DAO, respectively, at a low substrate concentration. In contrast, benzylamine, tyramine, and β-phenylethylamine served as substrates for all of MAO-A, MAO-B, and SSAO. Each amine oxidase showed broad substrate selectivity at a high substrate concentration. The cross-inhibition was remarkable in MAO-A and MAO-B, especially in MAO-A, but not in SSAO and DAO. A study of the substrate selectivity of amine oxidases should include consideration of the effects of substrate concentration and specific chemical inhibitors.

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