血小板粘着,細胞接着性を制御したコラーゲンの血管修復材への応用  [in Japanese] Control of Platelet Adhesion and Cell Attachment to He^+ Ion Irradiated Collagen for the Development of Small Diameter Vascular Graft Material  [in Japanese]

Our previous study indicated that He^+ -irradiated collagen grafts with a fluence of 1×10^<14> ions/cm^2 have excellent blood compatible properties. Also, the collagen grafts demonstrated a high antithrombogenicity and graft patency. 150 keV-He^+ irradiated collagen with a fluence of 1×10^<14> ions/cm^2 simultaneously has the 2 properties of antithrombogenicity and cell attachment. In vitro platelet adhesion and plasma protein adsorption were evaluated to investigate the mechanisms of antithrombogenicity of these surfaces. Antithrombogenicity of the He^+ -irradiated collagen was caused by the reduction of the plasma protein adsorption such as the von Willebrand factor by ion beam irradiation. He^+ -irradiated collagen surfaces will be useful for the substrates of small-diameter vascular grafts.