Survival Change of Ventral Mesencephalon-Derived Progenitor Cells after Grafting into Unilateral Intact Adult Rat Striatum

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  • PARK Moon Seok
    Division of Life Science, College of Natural Sciences and Applied Life Science (Brain Korea 21), Gyeongsang National University
  • LEE Hae Young
    Division of Life Science, College of Natural Sciences and Applied Life Science (Brain Korea 21), Gyeongsang National University
  • LI Shu Peng
    Division of Life Science, College of Natural Sciences and Applied Life Science (Brain Korea 21), Gyeongsang National University
  • KOH Phil-Ok
    Department of Anatomy, College of Veterinary Medicine and Institute of Animal Medicine, Gyeongsang National University
  • BAHK Jong Yoon
    Department of Urology, College of Medicine, Gyeongsang National University
  • CHUNG Bong Chul
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology
  • KIM Myeong Ok
    Division of Life Science, College of Natural Sciences and Applied Life Science (Brain Korea 21), Gyeongsang National University

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Neural transplantation is one of the most promising treatments for neurodegenerative disorders. Survival rates of embryonic dopamine (DA) neurons following transplantation are low, between 2% and 20% in a number of animal models. To further establish survival changes of the transplanted gestational day 13.5 ventral mesencephalic (VM) cells into left intact adult rat striata so that design strategies of increasing survival of DA neurons, the tyrosine hydroxylase (TH) expression of VM-derived progenitor cells has been examined using immunohistochemistry and Western blot analysis. TH immunostaining revealed that the grafted VM cells developed to mature TH-positive neurons strongly at 3 weeks, peaked at 4 weeks, thereafter, gradually dropped following the degenerative expression of the grafted cells at both 5 and 6 weeks after transplantation. Western blot analysis also showed that the TH proteins were maximally expressed at 4 weeks post-grafting. Our finding suggested that the peak of surviving VM-derived TH positive cells occurred approximately 4 weeks after transplantation.<br>

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