胃癌術後１２年目に発症した骨転移の１例

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  • A Case of Bone Metastasis from Gastric Carcinoma after Twelve-year Disease-Free Interval

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We present a case of very late and unusual recurrence of gastric carcinoma. A 54-year-old man underwent total gastrectomy with D3 LN cleaning for gastric carcinoma in April 1992.Histologically, the tumor was signetring cell carcinoma stage II (T2, N1, P0, H0, M0). Postoperatively, he was treated with oral 5-fluorouracil and PSK for three years without evidence of recurrence. He suddenly developed lumbago in August 2004 and was diagnosed with a pressure fracture at the thoracic and lumbar spine. Pathologic fracture was suspected, so we conducted bone biopsy. Histologically, the biopsy specimen was signet-ring cell carcinoma, leading to a diagnosis of multiple bone metastasis from gastric carcinoma. Chemotherapy and radiotherapy were started using a regimen of S-1 (80mg/body weight) +CDDP (10mg/body weight) and 30Gy for the thoracic and lumbar spine. Tumor markers decreased and pain was relieved, but the man was died of disseminated intravascular coagulation two months later.

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