Protective Effect of Salvianic Acid A on Acute Liver Injury Induced by Carbon Tetrachloride in Rats
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- Wang Chao-Yun
- Department of Pharmacology, Xi'an Jiaotong University School of Medicine Shandong Engineering Research Center for Nature Drug
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- Ma Fu-Lu
- Shandong Engineering Research Center for Nature Drug
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- Liu Jun-Tian
- Department of Pharmacology, Xi'an Jiaotong University School of Medicine
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- Tian Jing-Wei
- Shandong Engineering Research Center for Nature Drug
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- Fu Feng-Hua
- Shandong Engineering Research Center for Nature Drug
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Previous research has shown that salvianic acid A [2-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid, SA] extracted from Salvia miltiorrhiza BGE (Danshen) markedly inhibits lipid peroxidation of mitochondrial membrane of hepatic cells in vitro. The present study was conducted to examine protective effect of SA on liver injury induced by carbon tetrachloride (CCl4) and its possible mechanism in vivo. Male Sprague-Dowley rats weighing 180—200 g were used in the experiments. Five mmol/kg CCl4 in olive oil was given to rats i.p. Spectrophotometrical method was used to measure activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum, activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) as well as malondialdehyde (MDA) level in hepatic tissue and the rate of superoxide anion (O2·−) generation in hepatic submitochondrial particles. Hepatic histological structure was observed under light microscopy. CCl4 caused significant changes of activities of the enzymes, MDA level, and the rate of O2·− generation and histopathological changes of acute hepatic injury were noted. SA reversed the significant changes induced by CCl4. These results demonstrate that SA produces protective action on acute hepatic injury induced by CCl4 via an antioxidative mechanism.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 30 (1), 44-47, 2007
公益社団法人 日本薬学会
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- CRID
- 1390001204626958080
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- NII論文ID
- 110006153264
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8589968
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- en
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- データソース種別
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