前立腺肥大イヌの下腹神経刺激尿道内圧上昇に対するシロドシン(KMD-3213)の作用(<特集>シロドシン)
書誌事項
- タイトル別名
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- Effect of Silodosin on Intraurethral Pressure Increase Induced by Hypogastric Nerve Stimulation in Dogs with Benign Prostatic Hyperplasia
- 前立腺肥大イヌの下腹神経刺激尿道内圧上昇に対するシロドシン(KMD-3213)の作用
- ゼンリツセン ヒダイ イヌ ノ カフク シンケイ シゲキ ニョウドウ ナイアツ ジョウショウ ニ タイスル シロドシン KMD 3213 ノ サヨウ
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We compared the urethral and cardiovascular effects of silodosin (selective α1A-adrenoceptor antagonist), a novel medication for benign prostatic hyperplasia (BPH), with those of tamsulosin (selective α1A/α1D-adrenoceptor antagonist) and naftopidil (selective α1D-adrenoceptor antagonist). We evaluated the effects of these three drugs on the increase in intraurethral pressure (IUP) induced by electrical stimulation of the hypogastric nerve in anesthetized dogs with spontaneous BPH. All three drugs dose-dependently reduced both the increase in IUP and the mean blood pressure (MBP). The rank order of potencies was tamsulosin>silodosin>naftopidil for the reductions in both IUP and MBP. However, the uroselectivity (ED15 value for hypotensive effect/ID50 value for reduction in IUP) of silodosin (uroselectivity, 19.8) was about 21 and 4 times higher than that of tamsulosin (0.939) and naftopidil (4.94), respectively. These data suggest that silodosin might be one of the most useful medications for dysuria in BPH patients.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 126 (Special_Issue), 225-230, 2006
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206128797568
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- NII論文ID
- 110006154999
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
- http://id.crossref.org/issn/00316903
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- NDL書誌ID
- 7865224
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可