ヒスタミンH_1受容体遺伝子発現機構を標的とするアレルギー疾患治療薬の意義(誌上シンポジウム)  [in Japanese] Role of Therapeutics for Allergic Diseases in Targeting Histamine H_1 Receptor Gene Expression(Symposium Review)  [in Japanese]

    • 福井 裕行 FUKUI Hiroyuki
    • 徳島大学大学院ヘルスバイオサイエンス研究部分子薬物学分野 Department of Molecular Pharmacology, Graduate School of Health Biosciences, The University of Tokushima

Abstract

Histamine H_1 receptors are down-regulated as one step in receptor desensitization. Five phosphorylation sites of the H_1 receptor seem to play a key role in receptor down-regulation. In contrast, an increase in the H_1 receptor expression level following its mRNA elevation was found in the nasal mucosa in hypersensitivity model rats. Up-regulation of the H_1 receptor was induced by the direct stimulation of the H_1 receptor. H_1 receptor up-regulation was suppressed by pretreatment with antiallergic agents.

Journal

Journal of the Pharmaceutical Society of Japan   [List of Volumes]

Journal of the Pharmaceutical Society of Japan 127(1), 15-25, 2007-01-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  18

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Codes

  • NII Article ID (NAID) :
    110006155006
  • NII NACSIS-CAT ID (NCID) :
    AN00284903
  • Text Lang :
    JPN
  • Article Type :
    REV
  • ISSN :
    00316903
  • NDL Article ID :
    8631801
  • NDL Source Classification :
    ZS51(科学技術--薬学)
  • NDL Call No. :
    Z19-411
  • DOI :
    10.1248/yakushi.127.15
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE