ADLibシステムを用いたモノクローナル抗体の迅速作製(誌上シンポジウム)  [in Japanese] ADLib System for Rapid and Flexible Design of Monoclonal Antibodies(Symposium Review)  [in Japanese]

    • 太田 邦史 OHTA Kunihiro
    • 独立行政法人理化学研究所中央研究所太田遺伝システム制御研究室 Genetic System Regulation Laboratory, RIKEN Discovery Research Institute

Abstract

Monoclonal antibodies (MAbs) have been utilized as research tools, as diagnostic reagents, and for antibody medicine. The preparation of MAbs involves laborious processes and normally takes months. Here we describe an ex vivo B cell-based antibody display system called the ADLib (Autonomously Diversifying Library) system, which enables us to select chicken B cell clones producing antibody against antigens of interest in a couple of weeks. The ADLib system is applicable to self- or highly conserved antigens, polysaccharide chains, peptides, and haptens.

Journal

Journal of the Pharmaceutical Society of Japan   [List of Volumes]

Journal of the Pharmaceutical Society of Japan 127(1), 81-89, 2007-01-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  14

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Cited by:  1

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Codes

  • NII Article ID (NAID) :
    110006155012
  • NII NACSIS-CAT ID (NCID) :
    AN00284903
  • Text Lang :
    JPN
  • Article Type :
    Journal Article
  • ISSN :
    00316903
  • NDL Article ID :
    8631965
  • NDL Source Classification :
    ZS51(科学技術--薬学)
  • NDL Call No. :
    Z19-411
  • DOI :
    10.1248/yakushi.127.81
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE