Comprehensive Analyses of Arrhythmogenic Substrates and Vulnerability to Ventricular Tachycardia in Left Ventricular Hypertrophy in Salt-Sensitive Hypertensive Rats
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- Kamei Kenichi
- First Department of Internal Medicine, Fukushima Medical University
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- Maehara Kazuhira
- First Department of Internal Medicine, Fukushima Medical University
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- Kimura Junko
- Department of Pharmacology, Fukushima Medical University
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- Ishibashi Toshiyuki
- First Department of Internal Medicine, Fukushima Medical University
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- Maruyama Yukio
- First Department of Internal Medicine, Fukushima Medical University
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Background The contribution of conduction disturbances to susceptibility to ventricular tachycardia (VT) has not been directly examined in the process of left ventricular hypertrophy (LVH). Methods and Results Dahl salt-sensitive (S) and -resistant rats were raised on a high-salt diet. After echocardiography, a fractionation study was conducted using wavelet transform analysis, which reflects conduction disturbances, recording of monophasic action potential (MAP), measurement of conduction velocity, and programmed extrastimuli for the induction of VT, as well as patch-clamp analysis at 10, 13 and 16 weeks (W) (n=7, each). Systolic blood pressure, wall thickness and MAP duration significantly increased at 10W in S rats, whereas conduction velocity decreased and MAP duration and the power of wavelet transform increased at 13W and 16W. Paired extrastimuli induced polymorphic VT only at 13W and 16W in S rats. VT frequency correlated inversely with conduction velocity and positively with MAP duration. Power of wavelet transform correlated negatively with conduction velocity and positively with VT vulnerability. The patch-clamp study revealed that the action potential duration significantly increased in S rats with aging, and correlated with MAP duration. Conclusions Latently progressing slow and inhomogeneous conduction, as well as a repolarization abnormality, may contribute to VT vulnerability in hypertensive LVH. (Circ J 2007; 71: 390 - 396)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 71 (3), 390-396, 2007
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205105791104
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- NII論文ID
- 110006224210
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可