Influences of Histamine H1 Receptor Antagonists on Maximal Electroshock Seizure in Infant Rats

• Ishikawa Takashi

  Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Takechi Kenshi

  Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Rahman Md. Ashequr

  Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Ago Jun

  Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Matsumoto Naotaka

  Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Murakami Aya

  Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Kamei Chiaki

  Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

抄録

The influences of histamine H₁ receptor antagonists on maximal electroshock seizure were studied using infant rats. In this study, electroconvulsion was induced by stimulating rats using ear-clip electrodes, and the durations of electroencephalogram (EEG) seizure, tonic extensor (TE) seizure and clonic (CL) seizure induced by maximal electroshock were measured. Diphenhydramine, chlorpheniramine, cyproheptadine and ketotifen caused a dose-dependent and significant prolongation of both EEG seizure and TE seizure induced by maximal electroshock. On the other hand, epinastine and fexofenadine caused no such effects, even at a dose of 50 mg/kg. All drugs used in this study showed no significant effect on CL seizure induced by maximal electroshock. From these findings, it is suggested that epinastine and fexofenadine may cause no harmful influence on epilepsy, even when used in a little child.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 30 (3), 477-480, 2007

  公益社団法人 日本薬学会

キーワード

• maximal electroshock
• tonic extensor seizure
• electroencephalogram seizure
• epinastine
• fexofenadine
• infant rat

詳細情報

• CRID: 1390001204624200192
• NII論文ID: 110006239188
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.30.477
• COI: 1:CAS:528:DC%2BD2sXkvVSntL8%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 8657849
• PubMed: 17329841
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8657849
• Web Site: http://www.jstage.jst.go.jp/article/bpb/30/3/30_3_477/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007232807
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可