An Herbal Medicine Orengedokuto Prevents Indomethacin-Induced Enteropathy
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- Miura Naoko
- Central Research Laboratories, Tsumura & Co.
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- Fukutake Masato
- Central Research Laboratories, Tsumura & Co.
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- Yamamoto Masahiro
- Central Research Laboratories, Tsumura & Co.
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- Ohtake Nobuhiro
- Central Research Laboratories, Tsumura & Co.
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- Iizuka Seiichi
- Central Research Laboratories, Tsumura & Co.
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- Imamura Sachiko
- Central Research Laboratories, Tsumura & Co.
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- Tsuchiya Naoko
- Central Research Laboratories, Tsumura & Co.
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- Ishimatsu Makoto
- Central Research Laboratories, Tsumura & Co.
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- Nakamura Yuichi
- Central Research Laboratories, Tsumura & Co.
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- Ishige Atsushi
- Department of Kampo Medicine, Keio University School of Medicine
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- Watanabe Kenji
- Department of Kampo Medicine, Keio University School of Medicine
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- Kase Yoshio
- Central Research Laboratories, Tsumura & Co.
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- Takeda Shuichi
- Central Research Laboratories, Tsumura & Co.
書誌事項
- タイトル別名
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- Herbal Medicine Orengedokuto Prevents Indomethacin Induced Enteropathy
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Prostaglandin E2 (PGE2) is a key regulator of gastrointestinal, immunological, and mucosal homeostasis. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the prostaglandin-producing enzyme cyclooxygenases (COXs), and can induce serious complications, such as gastrointestinal damage, with long-term treatment. Orengedokuto (OGT), a Japanese traditional herbal medicine (Kampo medicine), is effective in various animal models of enteropathy. In the present study we examined whether OGT prevents enteropathy induced by NSAIDs in mice. Ulceration in the small intestine was induced with 2 subcutaneous injections of indomethacin (20 mg/kg body weight). Orally administered OGT prevented or reduced lethality, intestinal lesions, bleeding, increased serum nitrate/nitrite levels, and reduction of mucosal PGE2 induced by indomethacin. These beneficial effects of OGT were accompanied by increased production of PGE2 and interleukin 10 by isolated lamina propria mononuclear cells; COX-2 in these cells may be a major source of PGE2 in normal intestines. These findings suggest that OGT could be an effective therapeutic agent for the treatment of inflammatory bowel disease and adverse reactions to NSAIDs.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 30 (3), 495-501, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679600904320
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- NII論文ID
- 110006239192
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8657900
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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