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A novel strategy to integrate various elements necessary for bioanalysis into a microchip was presented for developing a real micro total bioanalysis system. This dissertation focused on the integration of reaction fields into a microchip, the integration of chemical functions into a microchannel, and the integration of a detection system into a microchip. The integration of immunoassay into a multichannel microchip dramatically shortened the analysis time while reducing the amounts of the reagent and sample. Photochemical patterning of protein inside a microchannel allowed an expression of different chemical functions in a microchannel. The fabrication of an integrated microchip incorporating an LED and an optical fiber led to miniaturization of the entire analytical system, which enabled an on-site analysis. The techniques developed in this study would be useful for developing a real micro total bioanalysis system.
