既経口感作ラットの腸絨毛におけるアポトーシス発現上皮細胞を介した抗原粒子の体循環血へのパーソープションの仕組み
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- YUJI Midori
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- FUJIMOTO Masato
- Department of Animal Science, Graduate School of Science and Technology, Kobe University
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- MIYATA Hidenori
- Department of Animal Science, Graduate School of Science and Technology, Kobe University
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- INAMOTO Tetsurou
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- QI Wang-Mei
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- YAMAMOTO Kenkichi
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- WARITA Katsuhiko
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- YOKOYAMA Toshifumi
- Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University
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- HOSHI Nobuhiko
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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- KITAGAWA Hiroshi
- Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
書誌事項
- タイトル別名
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- Persorption Mechanisms of Luminal Antigenic Particulates via Apoptotic Epithelial Cells of Intestinal Villi into Systemic Blood Circulation in Orally Immunized Rats
- Anatomy: Persorption mechanisms of luminal antigenic particulates via apoptotic epithelial cells of intestinal villi into systemic blood circulation in orally immunized rats
この論文をさがす
抄録
The possibility of persorption of prefixed bovine serum albumin-coated sheep erythrocytes (BSA-SEs) from mucous epithelial cells and its mechanisms were investigated in rats orally immunized by BSA for 14 consecutive days. On the day after the final oral immunization, the rats were duodenally perfused by BSA-SEs or non-coated SEs. BSA-SEs were also duodenally perfused in non-immunized rats. Thirty min after perfusion, BSA-SEs were significantly more engulfed by late-apoptotic-stage villous columnar epithelial cells in the orally immunized rats than those in other experiments. The specific antibody (SpAb) was detected on the surfaces of BSA-SEs in rats with oral immunization. In Peyer's patches of all animals, no SEs reached the follicle-associated epithelium, because of the close attachment of follicle-associated intestinal villi and the thick mucous layer. BSA-SEs were more frequently persorbed into portal blood in the orally immunized rats than in other rats. Small numbers of BSA-SEs or SEs were detected in the systemic blood of all animals. BSA-SEs were also histologically found in the blood vessels of the liver, but not in mesenteric lymph nodes. These findings suggest that sensitized antigenic particulates are taken up by late-apoptotic-stage villous columnar epithelial cells in the small intestine and are finally persorbed into the systemic blood circulation. The uptake of antigenic particulates might be mediated by its luminal SpAb.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 69 (4), 339-346, 2007
公益社団法人 日本獣医学会
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詳細情報
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- CRID
- 1390282681406538880
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- NII論文ID
- 110006250073
- 130000447421
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 8806519
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可