Serum Adiponectin Level as an Independent Predictor of Mortality in Patients With Congestive Heart Failure Tamura Toshihiro Furukawa Yutaka Taniguchi Ryoji Sato Yukihito Ono Koh Horiuchi Hisanori Nakagawa Yoshihisa Kita Toru Kimura Takeshi 社団法人日本循環器学会 Circulation journal : official journal of the Japanese Circulation Society 13469843 71 5 623 630 2007-04-20 Background Congestive heart failure (CHF) is associated with altered energy homeostasis and myocardial inflammation, hypertrophy, and fibrosis. Adiponectin, an insulin-sensitizing adipocytokine, may affect these pathogenic factors, and the circulating adiponectin level may serve as a biological marker of CHF. This study aimed to assess the significance of serum adiponectin as a prognostic marker for Japanese CHF patients. Methods and Results The serum adiponectin levels were compared between 54 (24 ischemic and 30 nonischemic) CHF patients with left ventricular systolic dysfunction and 55 age- and gender-matched control subjects. The CHF patients also underwent simultaneous clinical assessment and measurements for brain natriuretic peptide (BNP) and parameters of lipid or glucose metabolism. Compared with the controls, the CHF patients showed significantly increased serum adiponectin levels [6.7 (4.9-12.6) vs 14.6 (9.7-25.4) μg/ml, p<0.0001]. In the CHF patients, the log-transformed values of the serum adiponectin levels positively correlated with the log-transformed values of the plasma BNP levels (p=0.0003, r=0.48) and inversely correlated with the body mass index (p=0.0006, r=-0.46). Furthermore, an increase in the serum adiponectin level was associated with higher mortality (p<0.05), particularly in the ischemic CHF patients (p<0.005). Conclusions An increase in the circulating adiponectin level was associated with higher mortality in the ischemic CHF patients. Adiponectin may be an informative risk marker for Japanese CHF patients. 2007-04-20 110006273593 AA11591968 ENG CJP CJPref NII-ELS J-STAGE 3 44 6 Serum Adiponectin Level as an Independent Predictor of Mortality in Patients With Congestive Heart Failure Tamura Toshihiro Furukawa Yutaka Taniguchi Ryoji Sato Yukihito Ono Koh Horiuchi Hisanori Nakagawa Yoshihisa Kita Toru Kimura Takeshi Japanese Circulation Society Circulation journal : official journal of the Japanese Circulation Society Background Congestive heart failure (CHF) is associated with altered energy homeostasis and myocardial inflammation, hypertrophy, and fibrosis. Adiponectin, an insulin-sensitizing adipocytokine, may affect these pathogenic factors, and the circulating adiponectin level may serve as a biological marker of CHF. This study aimed to assess the significance of serum adiponectin as a prognostic marker for Japanese CHF patients. Methods and Results The serum adiponectin levels were compared between 54 (24 ischemic and 30 nonischemic) CHF patients with left ventricular systolic dysfunction and 55 age- and gender-matched control subjects. The CHF patients also underwent simultaneous clinical assessment and measurements for brain natriuretic peptide (BNP) and parameters of lipid or glucose metabolism. Compared with the controls, the CHF patients showed significantly increased serum adiponectin levels [6.7 (4.9-12.6) vs 14.6 (9.7-25.4) μg/ml, p<0.0001]. In the CHF patients, the log-transformed values of the serum adiponectin levels positively correlated with the log-transformed values of the plasma BNP levels (p=0.0003, r=0.48) and inversely correlated with the body mass index (p=0.0006, r=-0.46). Furthermore, an increase in the serum adiponectin level was associated with higher mortality (p<0.05), particularly in the ischemic CHF patients (p<0.005). Conclusions An increase in the circulating adiponectin level was associated with higher mortality in the ischemic CHF patients. Adiponectin may be an informative risk marker for Japanese CHF patients. Tamura Toshihiro Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Furukawa Yutaka Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Taniguchi Ryoji Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Sato Yukihito Department of Cardiology, Hyogo Prefectural Amagasaki Hospital Ono Koh Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Horiuchi Hisanori Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Nakagawa Yoshihisa Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Kita Toru Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Kimura Takeshi Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine