Impact of Newly Diagnosed Abnormal Glucose Tolerance on Long-Term Prognosis in Patients With Acute Myocardial Infarction Tamita Koichi Katayama Minako Takagi Tsutomu Akasaka Takashi Yamamuro Atsushi Kaji Shuichiro Morioka Shigefumi Kihara Yasuki 社団法人日本循環器学会 Circulation journal : official journal of the Japanese Circulation Society 13469843 71 6 834 841 2007-05-20 Background Newly-diagnosed diabetes mellitus (DM) and impaired glucose tolerance are common among patients with acute myocardial infarction (AMI). However, its significance on long-term clinical outcomes in those patients remains unclear. The present study was designed to determine whether such abnormalities after AMI affect long-term clinical outcomes. Methods and Results Two-hundred and seventy-five AMI patients were prospectively enrolled. Eighty-five had diagnosed DM, while the other 190 did not. According to oral glucose tolerance tests at discharge, non-DM patients were divided into 2 groups: 78 patients with normal glucose tolerance and 112 patients with abnormal glucose tolerance. Patients were followed until they reached the primary endpoint: cardiovascular death or un-planned hospitalization due to major adverse cardiovascular events. The median follow-up period was 5.3 years. Kaplan-Meier survival curves for the abnormal glucose tolerance group were poorer than for normal glucose tolerance, and were equivalent to the pre-diagnosed DM group in prognosis (p<0.0005). Glucometabolic status was the strongest predictor for future cardiovascular events (hazard ratio to normal glucose tolerance; 2.65; confidence interval: 1.37-5.15; p=0.004 in abnormal glucose tolerance and 3.27:1.68-6.38; p=0.0005 in DM). Conclusions Abnormal glucose tolerance in patients with AMI is a major risk factor for future cardiovascular events and may critically distinguish high-risk individuals. 2007-05-20 110006273821 AA11591968 ENG CJP CJPref NII-ELS J-STAGE 3 40 5 Impact of Newly Diagnosed Abnormal Glucose Tolerance on Long-Term Prognosis in Patients With Acute Myocardial Infarction Tamita Koichi Katayama Minako Takagi Tsutomu Akasaka Takashi Yamamuro Atsushi Kaji Shuichiro Morioka Shigefumi Kihara Yasuki Japanese Circulation Society Circulation journal : official journal of the Japanese Circulation Society Background Newly-diagnosed diabetes mellitus (DM) and impaired glucose tolerance are common among patients with acute myocardial infarction (AMI). However, its significance on long-term clinical outcomes in those patients remains unclear. The present study was designed to determine whether such abnormalities after AMI affect long-term clinical outcomes. Methods and Results Two-hundred and seventy-five AMI patients were prospectively enrolled. Eighty-five had diagnosed DM, while the other 190 did not. According to oral glucose tolerance tests at discharge, non-DM patients were divided into 2 groups: 78 patients with normal glucose tolerance and 112 patients with abnormal glucose tolerance. Patients were followed until they reached the primary endpoint: cardiovascular death or un-planned hospitalization due to major adverse cardiovascular events. The median follow-up period was 5.3 years. Kaplan-Meier survival curves for the abnormal glucose tolerance group were poorer than for normal glucose tolerance, and were equivalent to the pre-diagnosed DM group in prognosis (p<0.0005). Glucometabolic status was the strongest predictor for future cardiovascular events (hazard ratio to normal glucose tolerance; 2.65; confidence interval: 1.37-5.15; p=0.004 in abnormal glucose tolerance and 3.27:1.68-6.38; p=0.0005 in DM). Conclusions Abnormal glucose tolerance in patients with AMI is a major risk factor for future cardiovascular events and may critically distinguish high-risk individuals. Tamita Koichi Department of Cardiovascular Medicine, Kobe General Hospital Katayama Minako Department of Cardiovascular Medicine, Kobe General Hospital Takagi Tsutomu Department of Cardiovascular Medicine, Kobe General Hospital Akasaka Takashi Department of Cardiovascular Medicine, Kobe General Hospital (Present address)Division of Cardiology, Wakayama Medical University Yamamuro Atsushi Department of Cardiovascular Medicine, Kobe General Hospital Kaji Shuichiro Department of Cardiovascular Medicine, Kobe General Hospital Morioka Shigefumi Department of Cardiovascular Medicine, Kobe General Hospital Kihara Yasuki Department of Cardiovascular Medicine, Kobe General Hospital