トナカイ(Rangifer tarandus)の銅中毒(病理学)  [in Japanese] Copper Poisoning in a Reindeer (Rangifertarandus)  [in Japanese]

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Abstract

2003年7月に千葉県の動物園において,7歳2カ月齢の雄のトナカイが,数日間軟便を呈した後に急死した。剖検時,肝臓は暗褐色を呈していた。病理組織学的に,肝実質中に変性した好中球の浸潤を伴う小壊死巣が散見され,大量のヘモジデリンを含有するKupffer細胞が多数認められた。肝細胞の細胞質には多数の銅染色陽性顆粒と空胞が認められた。銅の含有量は,肝臓266.6ppm,腎臓21.7ppm,血液197.8μg/dlであり,健康なトナカイおよび羊に比べ明らかに高い値であった。これらの結果より本症例をトナカイの銅中毒と診断した。

A seven-year-two-month-old male reindeer showed soft feces for several days, and suddenly died at a zoo in Chiba Prefecture in July 2003. Macroscopically, the liver was dark brown. Histopathologically, small necrotic foci were accompanied by degenerated neutrophils in the liver, and many Kupffer cells contained abundant hemosiderin. In addition, numerous copper stain-positive granules and small vacuoles were prominent in the cytoplasm of hepatocytes. The copper contents in liver, kidney and blood were 266.6 ppm, 21.7 ppm and 197.75μg/dl, respectively. These levels were apparently higher than those in the healthy reindeer and/or sheep. This reindeer was diagnosed as a case of copper poisoning.

Journal

Japanese Journal of Zoo and Wildlife Medicine   [List of Volumes]

Japanese Journal of Zoo and Wildlife Medicine 12(1), 71-76, 2007-03  [Table of Contents]

Japanese Society of Zoo and Wildlife Medicine

References:  28

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Codes

  • NII Article ID (NAID) :
    110006277190
  • NII NACSIS-CAT ID (NCID) :
    AA11366156
  • Text Lang :
    JPN
  • Article Type :
    NOT
  • ISSN :
    13426133
  • Databases :
    CJP  NII-ELS