Simultaneous Spectrophotometric Determination of Levodopa and Carbidopa in Pharmaceutical Formulations and Water Samples by Using Mean Centering of Ratio Spectra and H-Point Standard Addition Methods

• Madrakian Tayyebeh

  Faculty of Chemistry, Bu-Ali Sina University

• Mohammadnejad Massoumeh

  Faculty of Chemistry, Bu-Ali Sina University

抄録

Two spectrophotometric methods are described for the simultaneous determination of binary mixtures of carbidopa and levodopa in pharmaceutical formulations, without prior separation steps, using the mean centering of ratio spectra and H-point standard addition methods (HPSAM). The methods are based on the difference in the absorption spectra for the products of the reaction of carbidopa and levodopa with 4-aminobenzoic acid in the presence of periodate ion at pH 4.0. The methods allow rapid and accurate determination of carbidopa and levodopa. The results showed that the methods were capable to simultaneous determination of 0.30—10.00 μg ml⁻¹ and 0.50—10.00 μg ml⁻¹ each of carbidopa and levodopa. The proposed methods were successfully applied to the simultaneous determination of carbidopa and levodopa in pharmaceutical samples.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 55 (6), 865-870, 2007

  公益社団法人 日本薬学会

キーワード

• carbidopa
• levodopa
• simultaneous determination
• spectrophotometry

詳細情報

• CRID: 1390001204170577152
• NII論文ID: 110006278687
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.55.865
• COI: 1:STN:280:DC%2BD2szivVChtg%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 8740999
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8740999
• Web Site: http://www.jstage.jst.go.jp/article/cpb/55/6/55_6_865/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007316662
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可