Studies on Syntheses and Reactions of Methoxypyridazines. I. Methoxylation of 3,4,5-Trichloropyridazine(Organic,Chemical)

• 長島 弘

  Gifu Pharmaceutical University

• 小田 博久

  Gifu Pharmaceutical University

• 肥田 準一

  Gifu Pharmaceutical University

• 鍛冶 健司

  Gifu Pharmaceutical University

抄録

The reaction of 3,4,5-trichloropyridarine (1) with 1 eq amount of NaQMe resulted in the formation of three dichloromonomethoxypyridazines (2,3-OMe; 3,4-OMe; 4,5-OMe) in the ratio of 1:3:6. The 4-OMe compound 3 was isolated from the reaction mixture and the 3-OMe compound 2 was synthesized independently. Further methoxylation of 2, 3 and 4 was also investigated in order to prepare various substituted pyridazines.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 35 (1), 421-424, 1987-01-25

  公益社団法人日本薬学会

キーワード

• 3,4.5-trichloropyridazine
• methoxylation
• dichloromonomethoxypyridazine
• monochlorodimethoxypyridazine
• pyridazinone
• 3,4,5-trimethoxypyridazine

詳細情報

• CRID: 1571698602255256192
• NII論文ID: 110006280917
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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