Studies on Uricosuric Diuretics. II. : 6,7-Dichloro-4-nitro-, 6,7-Dichloro-4-sulfamoyl- and 6,7-Dichloro-4-acyl-2,3-dihydrobenzofuran-2-carboxylic Acids(Medeicinal Chemistry,Chemical)
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- HARADA HIROSHI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- MATSUSHITA YOSHIHIRO
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- YODO MITSUAKI
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- NAKAMURA MASUHISA
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- YONETANI YUKIO
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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抄録
2,3-Dihydrobenzofuran-2-carboxylic acids substituted with electronegative nitro, acyl and sulfamoyl groups at the 4-position were synthesized and tested for oral diuretic and saluretic activities in rats and mice. The intraperitoneal uricosuric activity was also tested by a clearance method using oxonate-treated rats. The 4-nitro compounds (11b, 12b, 13b and 14b) showed more potent saluretic activity than the corresponding 5-nitro compounds (7b, 18b, 19b and 20). Although the 5-acyl compounds were reported to show potent saluretic activities, the 4-acyl compounds (41a and b) had much lower activities. On the other hand, the saluretic activities of the 4-sulfamoyl compounds (22a-e) were as potent as those of the 5-sulfamoyl compounds reported previously. Uricosuric activity was found in 14b and 22a.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 35 (8), 3215-3226, 1987-08-25
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1574231877045977728
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- NII論文ID
- 110006281399
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- en
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- データソース種別
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