Further Metabolism of 4-Acetylaminoantipyrine, the Major Metabolite of Aminopyrine, in Rats(Pharmacological)
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A significant reduction of urinary excretion of 4-acetylaminoantipyrine (AcAA) after administration of aminopyrine was observed in rats treated with phenobarbital or with 3-methylcholanthrene. Urinary excretion data and results obtained in the isolated rat hepatocyte system clearly demonstrated that both an alternative route of metabolism of 4-aminoantipyrine, an AcAA precursor, and further metabolism of AcAA itself accounted for the considerable reduction of AcAA recovery. The further metabolism of AcAA, which had been regarded as one of the final metabolic products of aminopyrine, was especially enhanced by 3-mcthylcholanthrene pretreatment.