SYNTHESIS OF BREDININ 5'-ALKYLPHOSPHATES INVOLVING PHOTOCHEMICAL MANIPULATION OF THE IMIDAZOLE MOIETY, AND THEIR ANTITUMOR ACTIVITIES(Communications to the Editor)

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Abstract

Bredinin 5'-oleyl and 5'-cetyl phosphates (2a and 2b), prepared from 1-β-D-ribofuranosyl-5-aminoimidazole-4-carboxamide via a photochemical ring-opening reaction of the imidazole moiety, showed remarkable antitumor effects against various transplantable mouse tumors, and were clearly superior to bredinin (1).

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 35(8), 3523-3526, 1987-08-25  [Table of Contents]

The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID) :
    110006281447
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • ISSN :
    00092363
  • Databases :
    NII-ELS