SYNTHESIS OF BREDININ 5'-ALKYLPHOSPHATES INVOLVING PHOTOCHEMICAL MANIPULATION OF THE IMIDAZOLE MOIETY, AND THEIR ANTITUMOR ACTIVITIES(Communications to the Editor)

• Shuto Satoshi

  Research Laboratories, Toyo Jozo Co., Ltd

• Itoh Hiromichi

  Research Laboratories, Toyo Jozo Co., Ltd

• Endo Eriko

  Research Laboratories, Toyo Jozo Co., Ltd

• Fukukawa Kiyofumi

  Research Laboratories, Toyo Jozo Co., Ltd

• Tsujino Masatoshi

  Research Laboratories, Toyo Jozo Co., Ltd

• Ueda Tohru

  Faculty of Pharmaceutical Sciences, Hokkaido University

抄録

Bredinin 5'-oleyl and 5'-cetyl phosphates (2a and 2b), prepared from 1-β-D-ribofuranosyl-5-aminoimidazole-4-carboxamide via a photochemical ring-opening reaction of the imidazole moiety, showed remarkable antitumor effects against various transplantable mouse tumors, and were clearly superior to bredinin (1).

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 35 (8), 3523-3526, 1987-08-25

  公益社団法人日本薬学会

キーワード

• bredinin
• nucleoside antibiotic
• photochemical ring-opening reaction
• phosphorylation
• antitumor activity
• bredinin 5'-alkylphosphate
• AICA-riboside

詳細情報

• CRID: 1571980077232908416
• NII論文ID: 110006281447
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1988113522
• 本文言語コード: en
• データソース種別:
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