Development of a Stick-Type Transdermal Eyelid Delivery System of Ketotifen Fumarate for Ophthalmic Diseases

    • KIMURA Chiharu
    • College of Computer Science and Systems Engineering, Kyushu Institute of Technology
    • TOJO Kakuji
    • College of Computer Science and Systems Engineering, Kyushu Institute of Technology

Abstract

A transdermal eyelid delivery system for treating ocular diseases (eye-stick) has been developed. Ketotifen fumarate (KT) was used as a model drug. An in vivo study using rabbits showed that the eye-stick device maintained a constant conjunctival concentration of the drug for an extended period of time, which was equivalent or higher than the therapeutic level following eye drop administration. Moreover, the conjunctival concentration after eye-stick application was well predicted using the physicochemical parameters, diffusion coefficient and partition coefficient, obtained from in vitro hairless mouse skin permeation experiments.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(7), 1002-1005, 2007-07-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  14

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Codes

  • NII Article ID (NAID) :
    110006317161
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    00092363
  • NDL Article ID :
    8783500
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1002
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE