Design, Synthesis, and Antiangiogenic Effects of a Series of Potent Novel Fumagillin Analogues

    • LEE Hong Woo
    • New Drug Research Laboratories, Chong Kun Dang Research Institute
    • CHO Chin Sung
    • New Drug Research Laboratories, Chong Kun Dang Research Institute
    • KANG Sung Kwon
    • New Drug Research Laboratories, Chong Kun Dang Research Institute
    • YOO Yong Sang
    • New Drug Research Laboratories, Chong Kun Dang Research Institute
    • SHIN Jae Soo
    • New Drug Research Laboratories, Chong Kun Dang Research Institute
    • AHN Soon Kil
    • New Drug Research Laboratories, Chong Kun Dang Research Institute

Abstract

A series of fumagillin analogues containing the C6-substituted cinnamoyl moiety were designed, synthesized, and evaluated for antiangiogenic activity. Among them, 4-hydroxyethoxy-cinnamoyl fumagillol (4a) and 4-hydroxyethoxy-3,5-dimethoxycinnamoyl fumagillol (4d) exhibited more potent anti-proliferation activity in CPAE and HUVEC cells with low cytotoxicity in vitro. These compounds are presently under further pharmacological evaluation studies.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(7), 1024-1029, 2007-07-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  19

You must have a user ID to see the references.If you already have a user ID, please click "Login" to access the info.New users can click "Sign Up" to register for an user ID.

Preview

Preview

Codes

  • NII Article ID (NAID) :
    110006317166
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    00092363
  • NDL Article ID :
    8783916
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1024
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE