Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative

Abstract

Moderate acetylation of tomatidine with anhydrous acetic acid and pyridine for 20h at r.t., followed by pseudomerization in ice-water, gave a δ^<20(22)>-pseudo compound, which was then subjected to ozonolysis to provide a pregnane derivative in a total 54% yield showing neuritogenic and NGF-enhancing activities.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(7), 1077-1078, 2007-07-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  2

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Codes

  • NII Article ID (NAID) :
    110006317178
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    NOT
  • ISSN :
    00092363
  • DOI :
    10.1248/cpb.55.1077
  • Databases :
    CJP  NII-ELS  J-STAGE