Consumption of Sericin Suppresses Colon Oxidative Stress and Aberrant Crypt Foci in 1,2-Dimethylhydrazine-Treated Rats by Colon Undigested Sericin

• ZHAORIGETU Siquin

  Graduate School of Biosphere Science, Hiroshima University

• SASAKI Masahiro

  Graduate School of Biosphere Science, Hiroshima University

• KATO Norihisa

  Graduate School of Biosphere Science, Hiroshima University

抄録

This study was conducted to examine the mechanisms of the anti-colon tumor effect of dietary sericin. Dietary supplementation of 3% sericin reduced colon mucosal lipid peroxide and aberrant crypt foci in 1,2-dimethylhydrazine-treated rats. The colon content from sericin-fed rats had much stronger antioxidant activity compared to that from control rats not receiving sericin. The amino acid composition of undigested proteins in the colon contents from sericin-fed rats was similar to that of sericin ingested. The results suggest that the strong antioxidant activity of undigested sericin in the colon content causes lower oxidative stress and tumorigenesis in the colon.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 53 (3), 297-300, 2007

  一般財団法人 学会誌刊行センター

キーワード

• sericin
• resistant protein
• colon tumor
• aberrant crypt foci
• oxidative stress

詳細情報

• CRID: 1390282681302336384
• NII論文ID: 110006317292
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.53.297
• COI: 1:CAS:528:DC%2BD2sXns1OmtL0%3D
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 8785864
• PubMed: 17874837
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8785864
• Web Site: https://search.jamas.or.jp/link/ui/2008002023
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可