Decrease of the NADPH level in rat liver on oral administration of secondary autoxidation products of linoleic acid.

• ASHIDA Hitoshi

  Department of Utilization of Biological Resources, Kobe University

• KANAZAWA Kazuki

  Department of Agricultural Chemistry, Kobe University

• NATAKE Masato

  Department of Agricultural Chemistry, Kobe University

抄録

The hepatotoxicity of orally administered secondary autoxidation products of linoleic acid was investigated, as compared with the administration of a saline solution and linoleic acid as controls. The de novo synthesis of fatty acids was strongly reduced in the secondary products group. The level of NADPH in the liver significantly decreased while that of NADH did not. The activities of glucose-6-phosphate dehydrogenase and phosphogluconate dehydrogenase apparently decreased. The activities of NAD⁺ kinase and NAD⁺ synthetase decreased and that of NAD⁺ nucleosidase increased in the secondary products group. Therefore, the depletion of NADPH can be attributed to the inhibition of two metabolic systems (an NADPH-supplemental system, and a synthetic system of NADP and NAD), and resulted in the reduction of lipogenesis in the liver.

収録刊行物

• Agricultural and Biological Chemistry

  Agricultural and Biological Chemistry 51 (11), 2951-2957, 1987

  公益社団法人 日本農芸化学会

キーワード

• General Agricultural and Biological Sciences
• General Biochemistry, Genetics and Molecular Biology

詳細情報

• CRID: 1390282681440003968
• NII論文ID: 110006323161
• NII書誌ID: AA00515312
• DOI: 10.1271/bbb1961.51.2951
• COI: 1:CAS:528:DyaL1cXjtlamsw%3D%3D
• ISSN: 18811280
• ISSN: 00021369
• Web Site: https://search.jamas.or.jp/link/ui/1988101832
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可