Desmutagenicity of Furan Compounds towards Some Mutagens(Food & Nutrition)

    • KONG Zwe-Ling
    • Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University
    • SHINOHARA Kazuki
    • National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries
    • MITSUIKI Masata
    • Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University
    • MURAKAMI Hiroki
    • Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University

    • OMURA Hirohisa
    • Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University

Abstract

The effects of furan compounds, which were produced by the reactions of amino acids with sugars, were examined on the mutagenicity of some mutagens. Amino-carbonyl reaction mixtures of Phe and Cys and glucose or fructose in the presence of malic acid at 100℃ for 8 hr inhibited the mutagenicity of Trp-P-1 and Benzo[α]pyrene (B[α]P) toward Salmonella typhimurium TA 98 and TA 100. Furan compounds such as 5-hydroxymethyl-2-furfural, 5-methylfurfural, furfural, furfuryl alcohol, furan, 2-acetylfuran and 2-methylfuran also inhibited the mutagenicity of Trp-P-1, B[α]P and 2-aminofluorene toward TA 98 and TA 100 in the presence of S9 mix. The desmutagenic action of these furan compounds varied with the kind of mutagen. Among the furan compounds, 5-hydroxymethyl-2-furfural, furfural and 2-acetylfuran showed high desmutagenicity towards the mutagens used, while the desmutagenicity of furan and 5-methylfurfural was low.

Journal

Agricultural and biological chemistry   [List of Volumes]

Agricultural and biological chemistry 53(8), 2073-2079, 1989-08-23  [Table of Contents]

Japan Society for Bioscience, Biotechnology, and Agrochemistry

Cited by:  2

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Codes

  • NII Article ID (NAID) :
    110006324456
  • NII NACSIS-CAT ID (NCID) :
    AA00515312
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00021369
  • Databases :
    CJPref  NII-ELS  Journal@rchive 

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