Desmutagenicity of Furan Compounds towards Some Mutagens(Food & Nutrition)

    • KONG Zwe-Ling
    • Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University
    • SHINOHARA Kazuki
    • National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries
    • MITSUIKI Masata
    • Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University

    • MURAKAMI Hiroki
    • Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University
    • OMURA Hirohisa
    • Institute of Food Science and Technology, Faculty of Agriculture, Kyushu University

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Abstract

The effects of furan compounds, which were produced by the reactions of amino acids with sugars, were examined on the mutagenicity of some mutagens. Amino-carbonyl reaction mixtures of Phe and Cys and glucose or fructose in the presence of malic acid at 100℃ for 8 hr inhibited the mutagenicity of Trp-P-1 and Benzo[α]pyrene (B[α]P) toward Salmonella typhimurium TA 98 and TA 100. Furan compounds such as 5-hydroxymethyl-2-furfural, 5-methylfurfural, furfural, furfuryl alcohol, furan, 2-acetylfuran and 2-methylfuran also inhibited the mutagenicity of Trp-P-1, B[α]P and 2-aminofluorene toward TA 98 and TA 100 in the presence of S9 mix. The desmutagenic action of these furan compounds varied with the kind of mutagen. Among the furan compounds, 5-hydroxymethyl-2-furfural, furfural and 2-acetylfuran showed high desmutagenicity towards the mutagens used, while the desmutagenicity of furan and 5-methylfurfural was low.

Journal

Agricultural and biological chemistry   [List of Volumes]

Agricultural and biological chemistry 53(8), 2073-2079, 1989-08-23  [Table of Contents]

Japan Society for Bioscience, Biotechnology, and Agrochemistry

Cited by:  2

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Codes

  • NII Article ID (NAID) :
    110006324456
  • NII NACSIS-CAT ID (NCID) :
    AA00515312
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00021369
  • Databases :
    CJPref  NII-ELS  J-STAGE