Antifungal activity of the saponin fraction obtained from Asparagus officinalis L. and its active principle.
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- SHIMOYAMADA Makoto
- Department of Food Chemistry, Faculty of Agriculture, Tohoku University
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- SUZUKI Masayuki
- Central Research Laboratory, Dowa Mining Co., Ltd.
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- SONTA Hiromi
- Central Research Laboratory, Dowa Mining Co., Ltd.
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- MARUYAMA Makiko
- Central Research Laboratory, Dowa Mining Co., Ltd.
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- OKUBO Kazuyoshi
- Department of Food Chemistry, Faculty of Agriculture, Tohoku University
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Abstract
Antifungal activity was detected in the crude saponin fraction obtained from the bottom cut of Asparagus officinalis L. This activity was specific to certain fungi, for example Candida, Cryptococcus, Trichophyton, Microspomm and Epidermophyton. Attempts were made to isolate the active principles from this fraction; in this way a new saponin (AS-1) was isolated, and its structure was estimated to be 3-O-[{β-D-glucopyranosyl(1 →2)}{β-D-xylopyranosyl(1→4)-β-D-glucopyranosyl]-(25S), 5β-spirostan-3β-ol. The minimum inhibitory concentration (MIC) ranged from 0.5μg/ml to more than 8μg/ml depending upon the nature of the fungi. On the basis of the work carried out here, it is probable that asparagus will contain additional antifungal principles.
Journal
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- Agricultural and Biological Chemistry
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Agricultural and Biological Chemistry 54 (10), 2553-2557, 1990
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390001206460973952
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- NII Article ID
- 110006324604
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- NII Book ID
- AA00515312
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- ISSN
- 18811280
- 00021369
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed