Specific inhibition of insoluble glucan synthase (GTF-I) by maillard reaction products from casein and albumins.

• KOBAYASHI Shunsuke

  Central Research Laboratory, Godo-Shusei Co., Ltd.

• KOGA Kenji

  Central Research Laboratory, Godo-Shusei Co., Ltd.

• HAYASHIDA Osamu

  Central Research Laboratory, Godo-Shusei Co., Ltd.

• NAKANO Yamaji

  Central Research Laboratory, Godo-Shusei Co., Ltd.

• HASEGAWA Yasuhiro

  Central Research Laboratory, Godo-Shusei Co., Ltd.

Abstract

The Maillard reaction was done with several proteins and aldoses (glucose, glyceraldehyde, and glycolaldehyde) under both neutral and alkaline conditions. Maillard reaction products (MRP) from α_s-casein and albumins (ovalbumin, bovine serum albumin, human serum albumin, and α-lactalbumin) inhibited adhesive insoluble glucan synthesis by glucosyltransferase (GTF) of Streptococcus mutans. The magnitude of the inhibitory activity in MRP from αs-casein and the three aldoses correlated with the reactivity of the aldoses with proteins. The MRP from α_s-casein and albumins inhibited GTF-I and did not affect GTF-S, while their original proteins stimulated GTF-I specifically. These results suggest that the inhibitory activity of these MRP may be related to the GTF-I stimulating property of their original proteins.

Journal

• Agricultural and Biological Chemistry

  Agricultural and Biological Chemistry 54 (6), 1417-1424, 1990

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• General Agricultural and Biological Sciences
• General Biochemistry, Genetics and Molecular Biology

Details

• CRID: 1390001206463623680
• NII Article ID: 110006324967
• NII Book ID: AA00515312
• DOI: 10.1271/bbb1961.54.1417
• COI: 1:CAS:528:DyaK3cXkvFKht7k%3D
• ISSN: 18811280
• ISSN: 00021369
• ISSN: http://id.crossref.org/issn/00021369
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed