Bioactive Constituents from Chinese Natural Medicines. XXIII. Absolute Structures of New Megastigmane Glycosides, Sedumosides A_4, A_5, A_6, H, and I, and Hepatoprotective Megastigmanes from Sedum sarmentosum

Abstract

The methanol-eluted fraction of the hot water extract from the whole plant of Sedum sarmentosum (Crassu-laceae) was found to show hepatoprotective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the active fraction, five new megastigmane glycosides, sedumosides A_4, A_5, A_6, H, and I, were isolated together with 22 megastigmane constituents. Their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence. Among them, sedumoside F_1 (IC_<50>=47μM), (3S,5R,0S,9R)-megastigmane-3,9-diol (61μM), and myrsinionosides A (52μM) and D (62μM) were found to show the strong hepatoprotective activity.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(8), 1185-1191, 2007-08-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  34

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Cited by:  8

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Codes

  • NII Article ID (NAID) :
    110006366537
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    8824662
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1185
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE