Five New neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata with Cytotoxic Activities

    • CHEN Meng
    • School of Pharmaceutical Science, Yantai University
    • LIU Ke
    • School of Pharmaceutical Science, Yantai University
    • SHEN Li
    • School of Pharmaceutical Science, Yantai University

Abstract

Five new neo-clerodane diterpenoid alkaloids, named scutebarbatine G(1), 6,7-di-O-nicotinoylscutebarbatine G(2), 6-O-nicotinoyl-7-O-acetylscutebarbatine G(3), scutebarbatine H(4) and 7-O-nicotinoylscutebarbatine H(5) were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1-5 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC_<50> values in the range 3.4-8.5μM.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 55(8), 1218-1221, 2007-08-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  8

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Cited by:  1

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Codes

  • NII Article ID (NAID) :
    110006366543
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    00092363
  • NDL Article ID :
    8824856
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.55.1218
  • Databases :
    CJP  CJPref  NDL  NII-ELS  J-STAGE